From Fox News: A daily glass of orange juice might do more than deliver vitamin C. It may influence gene activity in ways that support heart health, according to new research.
In a small but detailed study, 20 healthy adults drank about two cups of 100% orange juice every day for two months.
Researchers from the University of São Paulo in Brazil, North Carolina State University and the University of California, Davis, tracked changes in more than 1,700 genes within participants’ immune cells, finding broad shifts in genetic activity tied to blood pressure, fat metabolism and inflammation — all key factors in cardiovascular health.
The findings highlight how citrus flavonoids — plant compounds also found in berries, tea and cocoa that act as antioxidants and anti-inflammatories — may influence the body at a molecular level. The research was published in the journal Molecular Nutrition & Food Research in late October.
Most participants in the study reportedly experienced lower inflammation and healthier blood vessel function.
Normal-weight participants showed shifts in inflammation-related genes, while those who were overweight displayed changes tied to fat metabolism and energy use, the report explained.
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Another article published on the NIH website in March of this year says, “Orange juice intake has been associated with several beneficial metabolic changes, which may influence cardiac remodeling induced by cardiovascular diseases.” The report continues:
Current opinion highlights how the metabolites and metabolic pathways modulated by orange juice consumption could potentially attenuate cardiac remodeling. It was observed that orange juice intake significantly modulates phospholipids, energy metabolism, endocannabinoid signaling, amino acids, and gut microbiota diversity, improving insulin resistance, dyslipidemia, and metabolic syndrome.
Specifically, modulation of phosphatidylethanolamine (PE) metabolism and activation of PPARα and PPARγ receptors, associated with improved energy metabolism, mitochondrial function, and oxidative stress, showed protective effects on the heart. Furthermore, orange juice intake positively impacted gut microbiota diversity and led to an increase in beneficial bacterial populations, correlated with improved metabolic syndrome. These findings suggest that orange juice may act as a metabolic modulator, with potential therapeutic implications for cardiac remodeling associated with cardiovascular diseases.
Daily orange juice has ‘therapeutic potential’ for genes and heart health, study finds https://t.co/65cxoWIMv2
— Fox News Lifestyle (@FoxNewsLife) November 18, 2025
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